Charlotte's Web to form scientific advisory board

Mr. Bill Morachnick reports CHARLOTTE'S WEB ANNOUNCES PLANS TO ESTABLISH A SCIENTIFIC ADVISORY BOARD Charlotte's Web Holdings Inc. is developing a scientific advisory board to accelerate its medical strategy and reinforce its legacy of science-backed innovation. The board will guide the company's research and development agenda, shape clinical initiatives, and help translate botanical science into impactful, patient-centred solutions. The scientific advisory board is expected to commence work in September, 2025. Founded over a decade ago with a mission to provide safe, plant-based wellness products, Charlotte's Web has consistently led the industry in research, safety and standardization. Its origin story -- centred around Charlotte Figi and the development of full-spectrum hemp genetics with naturally occurring CBD -- sparked a global movement and helped define the hemp health and wellness category. "Charlotte's Web was founded on the pillars of science, compassion and innovation," said Bill Morachnick, chief executive officer of Charlotte's Web. "Through our enduring partnership with the Realm of Caring, our products have been studied by leading institutions. The launch of our scientific advisory board marks a pivotal step forward -- deepening our commitment to expanding patient access to trusted, plant-based therapeutics." Charlotte's Web is scaling its medical channel strategy with support from its new scientific advisory board, which will advise on product formulations and practitioner education and engagement. To meet rising demand for clinically relevant CBD (cannabidiol) solutions, the company is also planning to create continuing medical education (CME) content for health care professionals. These initiatives address a critical gap in patient care by offering practitioner-informed options for supporting the management of health issues such as pain, anxiety and problematic sleep. This initiative also strengthens its partnership with DeFloria Inc., a collaboration including Charlotte's Web and Ajna BioSciences PBC, a botanical drug development company, focused on developing AJA001 (a full-spectrum CBD hemp extract) as a treatment for irritability associated with autism spectrum disorder. The botanical pharmaceutical candidate has received FDA (U.S. Food and Drug Administration) approval to proceed with its planned FDA phase 2 clinical trials. Leading the development of the board is Dr. Marcel Bonn-Miller, chief scientific officer, a world-renowned cannabinoid researcher with over 20 years of experience who has published approximately 200 research papers and is the co-inventor on multiple patents related to the use of CBD in neurodevelopmental disorders. "The establishment of our scientific advisory board is a critical step in advancing the clinical relevance of hemp-based therapeutics," said Dr. Bonn-Miller, chief scientific officer at Charlotte's Web. "Our focus is on translating rigorous cannabinoid research into real-world solutions. By aligning scientific expertise with practitioner needs, we're helping to shape a future where plant-based medicine is both accessible and evidence based." With this next chapter, Charlotte's Web continues to lead the evolution of cannabinoid science -- bridging research, clinical practice and patient care to set national standards in plant-based wellness. About Charlotte's Web Holdings Inc. Charlotte's Web, a certified B corporation headquartered in Louisville, Colo., is a botanical wellness innovation company and a market leader in hemp extract wellness that includes Charlotte's Web whole-plant, full-spectrum CBD extracts as well as broad-spectrum CBD and cannabinoid isolates. The company's hemp extracts have naturally occurring botanical compounds, including CBD, CBN (cannabinol), CBC (cannabichromene), CBG (cannabigerol), THC (tetrahydrocannabinol), terpenes, flavonoids and other beneficial compounds. Charlotte's Web product categories include CBD oil tinctures (liquid products), CBD gummies (sleep, calming, exercise recovery and immunity), CBN gummies, hemp-derived THC microdose gummies, functional mushroom gummies, CBD capsules, CBD topical creams and lotions, as well as CBD pet products for dogs. Through its substantially vertically integrated business model, Charlotte's Web maintains stringent control over product quality and consistency with analytic testing from soil to shelf for quality assurance. Charlotte's Web products are distributed to retailers and health care practitioners throughout the United States and are available on-line through the company's website. We seek Safe Harbor.