Charlotte's Web to form scientific advisory board

Executive Summary

• Charlotte's Web Holdings Inc. announced the establishment of a Scientific Advisory Board to guide its research and development agenda, shape clinical initiatives, and accelerate its medical strategy, with the board expected to commence work in September 2025.
• The company is scaling its medical channel strategy by creating continuing medical education (CME) content for healthcare professionals to address gaps in patient care for conditions such as pain, anxiety, and sleep issues.
• The release highlights the ongoing collaboration with DeFloria Inc. and Ajna BioSciences PBC regarding AJA001, a full-spectrum CBD hemp extract candidate that has received FDA approval to proceed with Phase 2 clinical trials for irritability associated with autism spectrum disorder.

Key Details

• Scientific Advisory Board:
  • Purpose: Guide R&D agenda, shape clinical initiatives, and translate botanical science into patient-centered solutions.
  • Start Date: Expected to commence work in September 2025.
  • Leadership: Dr. Marcel Bonn-Miller, Chief Scientific Officer, is leading the development of the board. He is a world-renowned cannabinoid researcher with over 20 years of experience, ~200 published research papers, and co-inventor on multiple CBD-related patents.
• Medical Channel Strategy:
  • The board will advise on product formulations and practitioner education/engagement.
  • Charlotte's Web plans to create CME content for healthcare professionals to support the management of pain, anxiety, and problematic sleep.
• Partnership and Clinical Trials:
  • Collaboration with DeFloria Inc. (a joint effort between Charlotte's Web and Ajna BioSciences PBC).
  • Focus: Developing AJA001 (a full-spectrum CBD hemp extract) as a treatment for irritability associated with autism spectrum disorder.
  • Status: AJA001 has received FDA approval to proceed with planned Phase 2 clinical trials.
• Company Background:
  • Charlotte's Web is a certified B corporation headquartered in Louisville, Colo.
  • Products include whole-plant full-spectrum CBD extracts, broad-spectrum CBD, cannabinoid isolates, tinctures, gummies, capsules, topicals, and pet products.
  • Distribution is through retailers, healthcare practitioners, and online channels in the United States.

Notable Quotes

• Bill Morachnick, CEO: "Charlotte's Web was founded on the pillars of science, compassion and innovation... The launch of our scientific advisory board marks a pivotal step forward -- deepening our commitment to expanding patient access to trusted, plant-based therapeutics."
• Dr. Marcel Bonn-Miller, Chief Scientific Officer: "The establishment of our scientific advisory board is a critical step in advancing the clinical relevance of hemp-based therapeutics... By aligning scientific expertise with practitioner needs, we're helping to shape a future where plant-based medicine is both accessible and evidence based."